Prospective Evaluation of Sleep Apnea as Manifestation of Heart Failure in Children
- den Boer, Susanna L.
- Joosten, Koen F. M.
- van den Berg, Sandra
- Backx, Ad P. C. M.
- Tanke, Ronald B.
- du Marchie Sarvaas, Gideon J.
- Helbing, Willem A.
- Rammeloo, Lukas A. J.
- ten Harkel, Arend D. J.
- van Iperen, Gabrielle G.
- Dalinghaus, Michiel
DOIAbstract
In adults with heart failure, central sleep apnea (CSA), often manifested as Cheyne-Stokes respiration, is common, and has been associated with adverse outcome. Heart failure in children is commonly caused by dilated cardiomyopathy (DCM). It is unknown whether children with heart failure secondary to DCM have CSA, and whether CSA is related to the severity of heart failure. In this prospective observational study, 37 patients (<18 year) with heart failure secondary to DCM were included. They underwent polysomnography, clinical and laboratory evaluation and echocardiographic assessment. After a median follow-up time of 2 years, eight patients underwent heart transplantation. CSA (apnea-hypopnea index [AHI] a parts per thousand yen1) was foun...
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