A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
- Manning, Alisa K.
- Hivert, Marie-France
- Scott, Robert A.
- Grimsby, Jonna L.
- Bouatia-Naji, Nabila
- Chen, Han
- Rybin, Denis
- Liu, Ching-Ti
- Bielak, Lawrence F.
- Prokopenko, Inga
- Amin, Najaf
- Barnes, Daniel
- Cadby, Gemma
- Hottenga, Jouke-Jan
- Ingelsson, Erik
- Jackson, Anne U.
- Johnson, Toby
- Kanoni, Stavroula
- Ladenvall, Claes
- Lagou, Vasiliki
- Lahti, Jari
- Lecoeur, Cecile
- Liu, Yongmei
- Martinez-Larrad, Maria Teresa
- Montasser, May E.
- Navarro, Pau
- Perry, John R. B.
- Rasmussen-Torvik, Laura J.
- Salo, Perttu
- Sattar, Naveed
- Shungin, Dmitry
- Strawbridge, Rona J.
- Tanaka, Toshiko
- van Duijn, Cornelia M.
- An, Ping
- de Andrade, Mariza
- Andrews, Jeanette S.
- Aspelund, Thor
- Atalay, Mustafa
- Aulchenko, Yurii
- Balkau, Beverley
- Bandinelli, Stefania
- Beckmann, Jacques S.
- Beilby, John P.
- Bellis, Claire
- Bergman, Richard N.
- Blangero, John
- Boban, Mladen
- Kumari, Meena
- Penninx, Brenda
DOIAbstract
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P <5 x 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individ...
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