An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan is mediated through regulation of protein synthesis that is under control of the mechanistic target of rapamycin complex 1 (mTORC1). As one of its activities, mTORC1 stimulates translation into the metabolic transcription factor CCAAT/Enhancer Binding Protein beta (C/EBP beta) isoform Liver-specific Inhibitory Protein (LIP). Regulation of LIP expression strictly depends on a translation re-initiation event that requires a conserved cis-regulatory upstream open reading frame (uORF) in the C/EBP beta-mRNA. We showed before that suppression of LIP in mice, reflecting reduced mTORC1-signaling at the C/EBP beta level, results in CR-type of metaboli...
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription f...
Over the past few years, there has been a growing interest in the interconnection between translatio...
Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of choleste...
An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan i...
An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan i...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
Ageing is associated with physical decline and the development of age-related diseases such as metab...
Ageing is associated with physical decline and the development of age-related diseases such as metab...
Aging and obesity are common risk factors for numerous chronic pathologies, and the compounding effe...
Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and...
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription f...
Over the past few years, there has been a growing interest in the interconnection between translatio...
Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of choleste...
An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan i...
An important part of the beneficial effects of calorie restriction (CR) on healthspan and lifespan i...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptat...
Ageing is associated with physical decline and the development of age-related diseases such as metab...
Ageing is associated with physical decline and the development of age-related diseases such as metab...
Aging and obesity are common risk factors for numerous chronic pathologies, and the compounding effe...
Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and...
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription f...
Over the past few years, there has been a growing interest in the interconnection between translatio...
Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of choleste...