The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users : pooling of UK evidence
- Turner, Katy
- Hutchinson, Sharon
- Vickerman, Peter
- Hope, Vivian
- Craine, Noel
- Palmateer, Norah Elizabeth
- May, Margaret
- Taylor, Avril
- De Angelis, Daniela
- Cameron, Sheila
- Parry, John
- Lyons, Margaret
- Goldberg, David J.
- Allen, Elizabeth
- Hickman, Matthew
DOIAbstract
Aims To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs). Design Meta-analysis and pooled analysis, with logistic regression allowing adjustment for gender, injecting duration, crack injecting and homelessness. Setting Six UK sites (Birmingham, Bristol, Glasgow, Leeds, London and Wales), community recruitment. Participants A total of 2986 IDUs surveyed during 2001-09. Measurement Questionnaire responses were used to define intervention categories for OST (on OST or not) and high NSP coverage (≥100% versus <100% needles per injection). The primary outcome was new HCV infection, measured as antibody seroconversio...
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