Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
- Broekgaarden, M.
- Van Vught, R.
- Oliveira, Sabrina
- Roovers, R. C.
- Van Bergen En Henegouwen, P. M P
- Pieters, R. J.
- Van Gulik, T. M.
- Breukink, E.
- Heger, M.
Publication date
March 2016
DOI Publisher
Royal Society of Chemistry (RSC) ISSN
2040-3364Abstract
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested
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