Abstract Introduction Experiencing the disappearance of a loved one is a unique type of loss that may heighten the risk of developing prolonged grief (PG), depression, and posttraumatic stress (PTS) symptoms. Little is known about protective and risk factors for psychopathology among relatives of missing persons. A potential protective factor is self-compassion. Being more self-compassionate might block ruminative thinking (about the causes and consequences of the disappearance) and, thereby, prevent the maintenance and exacerbation of emotional distress. We aimed to test 1) if greater self-compassion is related to less PG, depression, and PTS levels in relatives of missing persons and 2) to what extent these associations are mediated by gr...