A multivariable model to guide the decision for pessary placement to prevent preterm birth in women with a multiple pregnancy: a secondary analysis of the ProTWIN trial
- Tajik, P.
- Monfrance, M.
- van't Hooft, J.
- Liem, S. M. S.
- Schuit, E.
- Bloemenkamp, K. W. M.
- Duvekot, J. J.
- Bijvank, B. Nij
- Franssen, M. T. M.
- Oudijk, M. A.
- Scheepers, H. C. J.
- Sikkema, J. M.
- Woiski, M.
- Mol, B. W. J.
- Bekedam, D. J.
- Bossuyt, P. M.
- Zafarmand, M. H.
DOIAbstract
Objective The ProTWIN Trial (NTR1858) showed that, in women with a multiple pregnancy and a cervical length <25th percentile (38 mm), prophylactic use of a cervical pessary reduced the risk of adverse perinatal outcome. We investigated whether other maternal or pregnancy characteristics collected at baseline can improve identification of women most likely to benefit from pessary placement. Methods ProTWIN is a multicenter randomized trial in which 808 women with a multiple pregnancy were assigned to pessary or control. Using these data we developed a multivariable logistic model comprising treatment, cervical length, chorionicity, pregnancy history and number of fetuses, and the interaction of these variables with treatment as predictors of...
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