Add to ORKGThe RP-HPLC determination of drug lipophilicity was evaluated for its potency as a substitute for the determination of log P(Oct-W) values. The relation of log k(w) to log P(app) (= log P(Oct-W) at pH 7.4) is linear for a testset including protonable nitrogen bases. The method is reproducible on different columns (with the same brand and type of the stationary phases) and needs no recalibration then. Three series of substituted benzene homologues (one hydrogen bond acceptor and two weak donor groups) demonstrate structure-retention effects
The correlation between reversed-phase liquid chromatographic (RPLC) capacity ratios and n-octanol w...
Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic ac...
This paper describes the evaluation of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benz...
The RP-HPLC determination of drug lipophilicity was evaluated for its potency as a substitute for th...
Abstract: HPLC provides a user's friendly, rapid, and compound sparing methodology, which is su...
Lipophilicity was evaluated by the high-throughput RP-HPLC method. A set of 40 solutes with well-def...
RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but re...
Reverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicit...
Different experimental strategies using short columns in both conventional liquid chromatography (HP...
The linear dependence of the logarithm of the capacity factor (log k') on the composition of th...
The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer c...
The potential biological activity of a molecule largely depends on its lipophilicity. The lipophilic...
The lipophilicity of aroma compounds was measured by reversed-phase high pressure liquid chromatogra...
The partition coefficients, P, between n-octanol and water of a number of growth stimulating substan...
The lipophilicity of aroma compounds was measured by reversed-phase high pressure liquid chromatogra...
The correlation between reversed-phase liquid chromatographic (RPLC) capacity ratios and n-octanol w...
Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic ac...
This paper describes the evaluation of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benz...
The RP-HPLC determination of drug lipophilicity was evaluated for its potency as a substitute for th...
Abstract: HPLC provides a user's friendly, rapid, and compound sparing methodology, which is su...
Lipophilicity was evaluated by the high-throughput RP-HPLC method. A set of 40 solutes with well-def...
RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but re...
Reverse phase high pressure liquid chromatography was employed in order to evaluate the lipophilicit...
Different experimental strategies using short columns in both conventional liquid chromatography (HP...
The linear dependence of the logarithm of the capacity factor (log k') on the composition of th...
The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer c...
The potential biological activity of a molecule largely depends on its lipophilicity. The lipophilic...
The lipophilicity of aroma compounds was measured by reversed-phase high pressure liquid chromatogra...
The partition coefficients, P, between n-octanol and water of a number of growth stimulating substan...
The lipophilicity of aroma compounds was measured by reversed-phase high pressure liquid chromatogra...
The correlation between reversed-phase liquid chromatographic (RPLC) capacity ratios and n-octanol w...
Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic ac...
This paper describes the evaluation of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benz...