Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis: a longitudinal study on plasma and glomerular eluates in MRL/1 mice

VanBruggen, MCJ
Kramers, C
Hylkema, MN
Smeenk, RJT
Berden, JHM

Publication date

July 1996

Abstract

The relationship between autoantibody reactivities and nephritis in systemic lupus erythematosus (SLE) is unclear. We studied MRL/1 mice which developed a considerable albuminuria (either mice with short (<1 week) or heavy and prolonged (3 weeks) albuminuria) and compared them with non-albuminuric age-matched controls, with young (12 weeks old) non-albuminuric mice and with mice which were followed for 36 weeks and did not develop albuminuria. In a longitudinal prospective study on plasma samples we correlated a variety of anti-nuclear reactivities and reactivities against extracellular matrix (ECM) components, with the onset of albuminuria. We found that at the onset of albuminuria, anti-DNA was higher while anti-nucleosome and anti-H2A/H2...

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Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis: a longitudinal study on plasma and glomerular eluates in MRL/1 mice

Abstract

Extracted data

Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis: a longitudinal study on plasma and glomerular eluates in MRL/1 mice

Abstract

Extracted data

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