Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4
- Ma, R. C. W.
- Hu, C.
- Tam, C. H.
- Zhang, R.
- Kwan, P.
- Leung, T. F.
- Thomas, G. N.
- Go, M. J.
- Hara, K.
- Sim, X.
- Ho, J. S. K.
- Wang, C.
- Li, H.
- Lu, L.
- Wang, Y.
- Li, J. W.
- Wang, Y.
- Lam, V. K. L.
- Wang, J.
- Yu, W.
- Kim, Y. J.
- Ng, D. P.
- Fujita, H.
- Panoutsopoulou, K.
- Day-Williams, A. G.
- Lee, H. M.
- Ng, A. C. W.
- Fang, Y-J.
- Kong, A. P. S.
- Jiang, F.
- Ma, X.
- Hou, X.
- Tang, S.
- Lu, J.
- Yamauchi, T.
- Tsui, S. K. W.
- Woo, J.
- Leung, P. C.
- Zhang, X.
- Tang, N. L. S.
- Sy, H. Y.
- Liu, J.
- Wong, T. Y.
- Lee, J. Y.
- Maeda, S.
- Xu, G.
- Cherny, S. S.
- Chan, T. F.
- Ng, M. C. Y.
- Xiang, K.
DOIAbstract
Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians. We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations. We identified CDKN2A/B and four novel type 2 diabetes association signals with p <1 x 10(-5) from the meta-analysis. Thirteen variants within these four loci were followed up in ...
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