Health-related quality of life and adverse late effects in adult (very) long-term childhood cancer survivors

Method: The RAND-36 was used to assess HRQoL in all adult (>= 18 years) survivors who had attended the long-term follow-up clinic since 1995. The survivors were divided into two groups based on the length of follow-up: Group LF (long term follow-up, follow-up 20 years, n = 184). Data on diagnosis, treatment and complications were obtained from medical records. Late effects were graded using the CTCAEv3. Results: The RAND-36 was completed by 313 (86.2%) out of 363 eligible patients. Except for higher scores on the subscale Bodily pain, LF patients did not differ significantly on the RAND-36 subscales from the population sample; VLF patients had significant lower scores on the subscales Physical functioning (P = 0.003), Social functioning, Vitality and General health perception (P <0.001). Significantly more VLF patients (P