Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig sequence, or better through advanced intermediate 9. The carbapenem carboxylates were chemically unstable; stability was not improved by changing the oxidation state of sulfur
Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S,N-het...
There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most impo...
Part A. Chapter 1. The Sharpless epoxidation product from E-4-phenyl-2-butene-1-ol and diethyl D-tar...
Abstract- Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig...
Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig sequence,...
Reaction of a ketone with a phosphorane produced a mixture of endocyclic and exocyclic carbapenem es...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
Reaction of azetidinone phosphoranes with an aldehyde gave olefins which were converted into carbape...
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and de...
The 4-substituted glutarimide required for the synthesis of sesbanimide (53) was obtained by free ra...
3-(1-tert-Butyldimethylsiloxyethyl)-4-phenylsulfinylazetidin-2-one reacted smoothly with various typ...
A stereoselective synthesis of 1β-aminocarbapenems (11a-c) starting from 4-acetoxy-2-azetidinone der...
International audienceThe carbapenem class of β-lactams has been optimized against Gram-negative bac...
Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carba...
The synthesis of tetrahydro-cis-cyclopenta[c]tiophene-5-one ethylenketal and its transformation into...
Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S,N-het...
There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most impo...
Part A. Chapter 1. The Sharpless epoxidation product from E-4-phenyl-2-butene-1-ol and diethyl D-tar...
Abstract- Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig...
Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig sequence,...
Reaction of a ketone with a phosphorane produced a mixture of endocyclic and exocyclic carbapenem es...
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
Reaction of azetidinone phosphoranes with an aldehyde gave olefins which were converted into carbape...
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and de...
The 4-substituted glutarimide required for the synthesis of sesbanimide (53) was obtained by free ra...
3-(1-tert-Butyldimethylsiloxyethyl)-4-phenylsulfinylazetidin-2-one reacted smoothly with various typ...
A stereoselective synthesis of 1β-aminocarbapenems (11a-c) starting from 4-acetoxy-2-azetidinone der...
International audienceThe carbapenem class of β-lactams has been optimized against Gram-negative bac...
Carboxymethylproline synthase (CarB) catalyzes the committed step in the biosynthesis of (R)-1-carba...
The synthesis of tetrahydro-cis-cyclopenta[c]tiophene-5-one ethylenketal and its transformation into...
Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S,N-het...
There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most impo...
Part A. Chapter 1. The Sharpless epoxidation product from E-4-phenyl-2-butene-1-ol and diethyl D-tar...
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