In spite of tremendous improvement in treatment of patients with angina pectoris due to significant coronary artery disease, there remains a group of patients who cannot adequately be treated. These patients are considered as having ‘intractale angina’. Patients, suffering from intractable ischemic disease have never been defined as a separate group and no data are available regarding their morbidity and mortality. Furthermore, since their angina was 'intractable’, no therapy was offered to improve the quality of life or life expectancy. In this thesis the efficacy of neurostimulation, a possible adjuvant therapy for these patients, is evaluated. Zie: Summar