Design and characterization of synthetic bilayer vesicles with a polymerized inner bilayer leaflet
- Ravoo, B.J
- Weringa, W.D
- Engberts, J.B.F.N.
DOIAbstract
Four new phospholipid derivatives containing a beta-nitrostyrene unit linked to the phosphate headgroup have been synthesized and converted into unilamellar vesicles. The vesicles were characterized by freeze-fracture transmission electron microscopy (FFEM), cryo-scanning electron microscopy (cryo-SEM), light scattering, and differential scanning calorimetry (DSC). At pH 11.5 and at T <T-m, the beta-nitrostyrene unit can be cleaved specifically exo-vesicularly. The cleavage process was analyzed in terms of a model providing independent rates of hydrolysis and flip-flop. Furthermore, the beta-nitrostyrene units can be polymerized yielding a polystyrene derivative. Neither the exo-vesicular cleavage nor the polymerization influence the morpho...
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