INTRODUCTION: As opposed to the routine use of nanomedicines for drug targeting to solid tumors, the highest medical need refers to targeting and treating metastasis. Little is known regarding the accumulation of polymers, liposomes and micelles in metastases, and no systematic analyses have been performed comparing drug targeting to different types (and sizes) of metastases. We here employ three different nanocarriers, an optically imageable metastatic mouse model and several different imaging techniques, to assess drug targeting and drug treatment of metastasis. With fluorophore-labeled nanomedicines, we show that metastases can be more efficiently targeted than primary tumors. In addition, we provide convincing proof-of-principle that do...
Despite considerable progresses in cancer treatment, tumor metastasis is still a thorny issue, which...
The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is inc...
Targeted therapeutics should accumulate at disease sites in higher quantities relative to other loca...
INTRODUCTION: As opposed to the routine use of nanomedicines for drug targeting to solid tumors, the...
Occult nodal metastases increase the risk of cancer recurrence, demoting prognosis and quality of li...
Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable s...
Tumor metastasis accounts for 90% of cancer-associated deaths and is almost inaccessible by chemothe...
Tumor metastasis is responsible for 90% of cancer-associated deaths and highly metastatic cancers ar...
Chemotherapeutic drugs have multiple drawbacks, including severe side effects and suboptimal therape...
While the enhanced permeability and retention effect may promote the preferential accumulation of na...
Metastatic brain cancers, in particular cancers with multiple lesions, are one of the most difficult...
Core-crosslinked polymeric micelles (CCPM) based on PEG-b-pHPMA-lactate are clinically evaluated for...
Highlights Small-sized trastuzumab-targeted micelles (T-MP) were engineered using a surfactant-strip...
Cancer nanomedicines are submicrometer-sized formulations designed to improve the biodistribution of...
Abstract—During metastasis, circulating tumor cells migrate away from a primary tumor via the blood ...
Despite considerable progresses in cancer treatment, tumor metastasis is still a thorny issue, which...
The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is inc...
Targeted therapeutics should accumulate at disease sites in higher quantities relative to other loca...
INTRODUCTION: As opposed to the routine use of nanomedicines for drug targeting to solid tumors, the...
Occult nodal metastases increase the risk of cancer recurrence, demoting prognosis and quality of li...
Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable s...
Tumor metastasis accounts for 90% of cancer-associated deaths and is almost inaccessible by chemothe...
Tumor metastasis is responsible for 90% of cancer-associated deaths and highly metastatic cancers ar...
Chemotherapeutic drugs have multiple drawbacks, including severe side effects and suboptimal therape...
While the enhanced permeability and retention effect may promote the preferential accumulation of na...
Metastatic brain cancers, in particular cancers with multiple lesions, are one of the most difficult...
Core-crosslinked polymeric micelles (CCPM) based on PEG-b-pHPMA-lactate are clinically evaluated for...
Highlights Small-sized trastuzumab-targeted micelles (T-MP) were engineered using a surfactant-strip...
Cancer nanomedicines are submicrometer-sized formulations designed to improve the biodistribution of...
Abstract—During metastasis, circulating tumor cells migrate away from a primary tumor via the blood ...
Despite considerable progresses in cancer treatment, tumor metastasis is still a thorny issue, which...
The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is inc...
Targeted therapeutics should accumulate at disease sites in higher quantities relative to other loca...