Add to ORKGThe treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies
Blood-brain barrier (BBB), a unique membrane barrier formed by closely stitched brain capillary endo...
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor progn...
Fang Zhang, Chun-Lei Xu, Chun-Mei Liu School of Pharmacy, National First-Class Key Discipline for T...
The treatment for central nervous system metastases of solid tumors and gliomas is limited as the bl...
Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug the...
Background: Malignant brain tumors are among the most challenging to treat and at present there are ...
As the most dangerous tumors, brain tumors are usually treated with surgical removal, radiation ther...
The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier (BTB), limit...
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor progn...
Brain tumors are responsible for almost 2% of deaths in the Western world. The most used methods now...
Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challen...
The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a sanctuary ...
Existing drug delivery methods have not led to a significant increase in survival for patients with ...
Because the brain is the most important human organ, many brain disorders can cause severe symptoms....
International audienceThe delivery of drugs to brain tumors is limited by the presence of the blood-...
Blood-brain barrier (BBB), a unique membrane barrier formed by closely stitched brain capillary endo...
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor progn...
Fang Zhang, Chun-Lei Xu, Chun-Mei Liu School of Pharmacy, National First-Class Key Discipline for T...
The treatment for central nervous system metastases of solid tumors and gliomas is limited as the bl...
Worldwide, the incidence of primary brain tumors is on the rise. Unfortunately, noninvasive drug the...
Background: Malignant brain tumors are among the most challenging to treat and at present there are ...
As the most dangerous tumors, brain tumors are usually treated with surgical removal, radiation ther...
The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier (BTB), limit...
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor progn...
Brain tumors are responsible for almost 2% of deaths in the Western world. The most used methods now...
Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challen...
The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a sanctuary ...
Existing drug delivery methods have not led to a significant increase in survival for patients with ...
Because the brain is the most important human organ, many brain disorders can cause severe symptoms....
International audienceThe delivery of drugs to brain tumors is limited by the presence of the blood-...
Blood-brain barrier (BBB), a unique membrane barrier formed by closely stitched brain capillary endo...
Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor progn...
Fang Zhang, Chun-Lei Xu, Chun-Mei Liu School of Pharmacy, National First-Class Key Discipline for T...