Cascade reactions in an all-enzyme nanoreactor

Good things come in small packages! Giant amphiphiles, consisting of a polymeric hydrophobic tail and a horseradish peroxidase head, were simultaneously synthesized and self-assembled into vesicles. During the self-assembly process, glucose oxidase was encapsulated to create enzymatic cascade nanoreactors (see picture; ABTS= 2,2′-azido-bis(3-ethylbenzthiazoline-6-sulfonic acid))