In this study we propose a new numerical algorithm for droplet-laden turbulent channel flow with phase transitions at low Mach numbers. The carrier gas is treated as compressible flow. In order to avoid very small time steps at low Mach numbers that would arise from stability requirements associated with explicit time-stepping we propose a new semi-explicit time integration method, applied to the low Mach number compressible flow equations. We perform a perturbation analysis in powers of the Mach number of the system of governing equations. The obtained decomposition of pressure into a space-independent part and a hydrodynamic part permits to apply a special pressure-based time integration algorithm for compressible flows at low Mach number...