The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2

Yulia Valer'evna Khasanova
Alsu Asatovna Nelaeva
Anna Borisovna Galkina
Irina Vasil'evna Medvedeva

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Publication date

March 2012

DOI

10.14341/2072-0351-5976

Publisher

UP Print

ISSN

2072-0378

Journal

issn:2072-0351

Abstract

Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM