CFD modeling of dispersed multiphase flows can be quite challenging because of the wide range of time- and length-scales involved. A modern methodology to bridge the different scales is multi-scale modeling, which involves applying different (types of) models to describe phenomena prevailing at different time and length scales. This approach requires however, closure equations for the unresolved sub-grid phenomena in the higher level models. These closures can in principle be obtained from analytical theory, experiments and direct numerical simulations (DNS), each with their own strong and weak points. Analytical theory is limited to idealized situations, for instance spherical bubbles in the limit of high Reynolds numbers, while experiment...