HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala)

Leucaena (Leucaena leucocephala) has been used as traditional medicine, such as<br />drugs to decrease the level of blood glucose, so it can be used as drug to indicate<br />diabetes. The aim of this research is to study the histopathological change of mice’s liver<br />given leucaena leaf extract. This research used 24 male mice that were divided into 4 groups<br />by completely randomized design. Group P0 (control) were given 0,9 % NaCl, and groups<br />P1, P2, and P3 were given 0,5 g / kg bw, 1 g / kg bw, and 1,5 g / kg bw leucaena’s leaf<br />extract by oral administration respectively. The treatment were given daily for 30 days. All of<br />the mice were necropsied at day 31, and the liver were taken to examine their<br />histopathological change. Histopathological change examination were based on the present<br />hydropic degeneration, fatty degeneration, and apoptosis surround central vein. Result of<br />statistically analised by ANOVA and Kruskal-Wallis method indicated no significance<br />difference among the control and treatments. There was no significance toxicity effect of<br />leucaena leaf extract of all treatment dosage on mice liver.<br />Keywords: Leucaena leucocephala, liver histology, Mus musculus L