Delivery of gentamicin from resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis

This thesis describes the development of gentamicin loaded resorbable polymeric carriers as anti-infective strategy for implant-associated osteomyelitis and their in vitro and in vivo evaluation. Local delivery of antibiotics has several advantages in the case of trauma to the bone and surrounding tissues. It can deliver high amounts of antibiotics directly to the target site, without inducing toxicity in non-target organs. Furthermore, sufficient antibiotic levels can be reached by local application at sites where the vasculature is disturbed