COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS

<p><strong>Abstract. </strong>The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium tuberculosis.</p><p>Similar differences in dynamics of some common parameters (life span and pathogen numbers in affected or gans) between A/Sn and I/St mice have been revealed for tuberculosis, salmonellosis and chlamidiasis. There has been demonstrated that A/Sn animals show increased resistance to Salmonella and Chlamidia infections, as compared to I/St mice, in spite of various mechanisms of intracellular parasitism for S.typhimurium and C.Pneumoniae, and different locations of lesions induced by these bacteria in the host organism.</p><p>Similar features of quite different infections at the level of macroorganism allows us to suggest that further investigation in A/Sn and I/St murine model will make it able to discover the basic features of physiolog$ical control for a lot of infections, and to reveal a genetic network that could be responsible for their favorable or adverse outcomes. <strong><em>(Med. Immunol., 2005, vol.7, № 5–6, pp. 583</em></strong><strong><em>–</em></strong><strong><em>586)</em></strong>