Genetic diagnostics of hereditary breast and ovarian cancer (HBOC) has been performed in Slovakia in many different forms before the year 2000. Complex HBOC genetic analysis consists of many steps, including the initial genetic consultation, laboratory testing of genes associated with HBOC, interpretation and report of DNA analysis results, secondary explanatory genetic consultation and recommendation of clinical management for pathological mutation carriers. Many clinicians are participating on this workflow, such as clinical geneticists, laboratory diagnosticians as well as gynaecologists, oncologists or radio-diagnosticians. Currently, genetic testing is still technically and financially demanding and aimed only at selected families or p...
In most cases, oncological diseases are hereditary: for breast cancer – 5–10%, and for ovarian cance...
BRCA1/BRCA2 mutations are the most common high penetrant genes associated with an increased lifetime...
Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a BRCA1 or BRCA2 mutat...
Hereditary breast and ovarian cancer (HBOC) is a syndrome defined by an increased risk of developing...
The diagnosis of inherited cancer-susceptibility syndromes can enable identifi cation of individuals...
Molecular diagnostics of hereditary breast and/or ovarian cancer is mainly based on detection of BRC...
Abstract The majority of hereditary breast and ovarian cancers can be accounted for by germline muta...
Abstract Purpose: Because many countries lack the capacity to follow the international guidelines f...
Abstract Approximately, 7 % of all breast cancers (BC) and 11–15 % of ovarian cancers (OC) are assoc...
Introduction > Next generation sequencing allows the simultaneous analysis of large panel of genes f...
Mama hereditaria; Cáncer de ovarios; Directrices SEOMMama hereditària; Càncer d'ovaris; Directrius S...
Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary br...
Hereditary breast and ovarian cancer (HBOC) follows an autosomal dominant inheritance pattern of can...
The counselling experience with 50 Flemish families in whom mutation analysis of the total coding re...
The importance of proper bioinformatics analysis and clinical interpretation of tumor genomic profil...
In most cases, oncological diseases are hereditary: for breast cancer – 5–10%, and for ovarian cance...
BRCA1/BRCA2 mutations are the most common high penetrant genes associated with an increased lifetime...
Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a BRCA1 or BRCA2 mutat...
Hereditary breast and ovarian cancer (HBOC) is a syndrome defined by an increased risk of developing...
The diagnosis of inherited cancer-susceptibility syndromes can enable identifi cation of individuals...
Molecular diagnostics of hereditary breast and/or ovarian cancer is mainly based on detection of BRC...
Abstract The majority of hereditary breast and ovarian cancers can be accounted for by germline muta...
Abstract Purpose: Because many countries lack the capacity to follow the international guidelines f...
Abstract Approximately, 7 % of all breast cancers (BC) and 11–15 % of ovarian cancers (OC) are assoc...
Introduction > Next generation sequencing allows the simultaneous analysis of large panel of genes f...
Mama hereditaria; Cáncer de ovarios; Directrices SEOMMama hereditària; Càncer d'ovaris; Directrius S...
Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary br...
Hereditary breast and ovarian cancer (HBOC) follows an autosomal dominant inheritance pattern of can...
The counselling experience with 50 Flemish families in whom mutation analysis of the total coding re...
The importance of proper bioinformatics analysis and clinical interpretation of tumor genomic profil...
In most cases, oncological diseases are hereditary: for breast cancer – 5–10%, and for ovarian cance...
BRCA1/BRCA2 mutations are the most common high penetrant genes associated with an increased lifetime...
Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a BRCA1 or BRCA2 mutat...