High-throughput screening of cell-surface topographic interactions

High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies