ABCB1 gene polymorphisms is not associated with drug-resistant epilepsy in Romanian children
- Butila Anamaria Todoran
- Sin Anca
- Szabo Elisabeta Racoş
- Micheu Cristian
- Moldovan Valeriu G.
- Voidazan Septimiu
- Bănescu Claudia
Publication date
December 2015
DOI Publisher
Sciendo ISSN
2284-5623 Journal
issn:2284-5623Abstract
Background: P-glycoprotein (P-gp), a drug efflux transporter, encoded by the gene MDR1 ABCB1 multidrug resistant, reduces the penetration through the brain by the AEDs. Overexpression of Pgp in blood-brain barrier in epileptic patients play an important rol in pharmacoresistance. The aim of this study was to evaluate a possible association between C1236T and G2677T ABCB1 gene polymorphisms and drug-resistant epilepsy in Romanian children
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