Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glutamate and may use it through oxidative glutamate dehydrogenase (GDH) activity. Here, we investigated the significance of glutamate as energy substrate for the brain. Upon glutamate exposure, astrocytes generated ATP in a GDH-dependent way. The observed lack of glutamate oxidation in brain-specific GDH null CnsGlud1−/− mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK in the hypothalamus. This induced changes in the autonomous nervous system ...
The brain requires a constant and substantial energy supply to maintain its main functions. For deca...
The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a centra...
Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and i...
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Gluta...
SummaryGlucose, the main energy substrate used in the CNS, is continuously supplied by the periphery...
The enzyme glutamate dehydrogenase (GDH; Glud1) catalyzes the (reversible) oxidative deamination of ...
Glutamate dehydrogenase (GDH), encoded by GLUD1, participates in the breakdown and synthesis of glut...
A key enzyme in brain glutamate homeostasis is glutamate dehydrogenase (GDH) which links carbohydrat...
Astrocyte end-feet surround intraparenchymal microvessels and represent therefore the first cellular...
Astrocyte end-feet surround intraparenchymal microvessels and represent therefore the first cellular...
Network activation triggers a significant energy metabolism increase in both neurons and astrocytes....
Glutamate is the main excitatory transmitter in the brain, while ATP represents the most important e...
The excitatory neurotransmitter glutamate has been reported to have a major impact on brain energy m...
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes ...
In this review, we analyze the current hypotheses regarding energy metabolism in the neurons and ast...
The brain requires a constant and substantial energy supply to maintain its main functions. For deca...
The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a centra...
Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and i...
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Gluta...
SummaryGlucose, the main energy substrate used in the CNS, is continuously supplied by the periphery...
The enzyme glutamate dehydrogenase (GDH; Glud1) catalyzes the (reversible) oxidative deamination of ...
Glutamate dehydrogenase (GDH), encoded by GLUD1, participates in the breakdown and synthesis of glut...
A key enzyme in brain glutamate homeostasis is glutamate dehydrogenase (GDH) which links carbohydrat...
Astrocyte end-feet surround intraparenchymal microvessels and represent therefore the first cellular...
Astrocyte end-feet surround intraparenchymal microvessels and represent therefore the first cellular...
Network activation triggers a significant energy metabolism increase in both neurons and astrocytes....
Glutamate is the main excitatory transmitter in the brain, while ATP represents the most important e...
The excitatory neurotransmitter glutamate has been reported to have a major impact on brain energy m...
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes ...
In this review, we analyze the current hypotheses regarding energy metabolism in the neurons and ast...
The brain requires a constant and substantial energy supply to maintain its main functions. For deca...
The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a centra...
Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells and i...