Add to ORKGThe synthesis and antiviral activity evaluation of new derivatives of 2-aminothiazole, 1,2,4-triazole, as well as oxindoles has been realized. The synthesized compounds exhibited different cytotoxicity, in particular, oxindols 4 , 5 , 7 , 8 , 9, 10, 11, 12, 13, 58 as well as thiazole/triazole 73 and 75 turned out to be the most cytotoxic for MT-4 cell lines. The compounds 11, 12, 73, and 75 are more toxic than reference compound Efavirenz. As far as the antiviral activity is concerned, none of the title compounds turned out active against Reo-1, Sb-1, VSV, RSV, YFV and VV viruses. The results obtained against Bovine Viral Diarrhoea Virus (BVDV) showed that nine compounds (six from oxindol’s seria 6, 12, 13, 52, 56, 58 and three 73, 75...
Copyright © 2012 Vinod Kumar Pandey et al. This is an open access article distributed under the Crea...
A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives...
BACKGROUND: Clinical drugs for herpesvirus exhibit high toxicity and suffer from significant drug re...
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives was prepared...
Chemistry Department, Lucknow University, Lucknow-226 007 Department of Virology, Central Drug Rese...
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential...
The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents u...
A series of novel 1,2,4-triazole derivatives has been designed and synthesized. All of the new compo...
The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents u...
A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- and...
In an attempt to synthesize pharmacologically active molecules, we report here the synthesis and in ...
New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized...
We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-ph...
A series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (7-15) and the thiadiazine analogues 16-18 hav...
2,4-dihydro-3H-1,2,4-triazol-3-one (5) was performed starting from 2-[4-amino-3-(4-methylphenyl)-5-o...
Copyright © 2012 Vinod Kumar Pandey et al. This is an open access article distributed under the Crea...
A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives...
BACKGROUND: Clinical drugs for herpesvirus exhibit high toxicity and suffer from significant drug re...
A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives was prepared...
Chemistry Department, Lucknow University, Lucknow-226 007 Department of Virology, Central Drug Rese...
In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential...
The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents u...
A series of novel 1,2,4-triazole derivatives has been designed and synthesized. All of the new compo...
The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents u...
A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- and...
In an attempt to synthesize pharmacologically active molecules, we report here the synthesis and in ...
New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized...
We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-ph...
A series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (7-15) and the thiadiazine analogues 16-18 hav...
2,4-dihydro-3H-1,2,4-triazol-3-one (5) was performed starting from 2-[4-amino-3-(4-methylphenyl)-5-o...
Copyright © 2012 Vinod Kumar Pandey et al. This is an open access article distributed under the Crea...
A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino-5-alkylthio derivatives...
BACKGROUND: Clinical drugs for herpesvirus exhibit high toxicity and suffer from significant drug re...