Multi-microelectrode devices for intrafascicular use in peripheral nerve

This minisymposium paper gives an overview of experimental, modeling, design and microfabrication steps which lead towards the University of Twente three-dimensional 128-fold silicon microelectrode device. The device is meant for implantation in peripheral nerve for neuromuscular control purposes and is estimated to be able to selectively control 10-20 motor fibres. Also, the potentialities of an alternative LIGA microfabrication technology are considered. A brief comparison is made with the two-dimensional sieve and flexible foil types of neuro electronic interfaces, under development elsewhere. Microfabrication technologies appear to be an important tool, but evidence is accumulating that for selective neuroelectronic interfacing the micro devices are not yet small/selective enough. More precision and selectivity is needed to contact individual axons intimately and selectively. Therefore, new lines of research develop towards in-vitro-neuron-cultured MEPs (Multi Electrode Plates) to be implanted in neural tissu