Control strategy to accomplish precise point-to-point posi- tioning and trajectory tracking of magnetically-guided mi- croparticles is analyzed in this work. External disturbances and model mismatch were modeled as inputs to the mag- netic force governing equation. First, the problem is formu- lated by modeling the magnetic force experienced by the microparticles in the presence of viscous drag, buoyancy force, force due to gravity, external disturbances and model mismatch [1]; the resulting model is utilized to design an observer to estimate the mismatch over the nominal and ac- tual values of these forces. Hereafter, the current-magnetic force map is derived by minimizing the two-norm square of the magnetic field-to-current map constraine...