The catastrophic Simushir earthquake occurred on 15 November 2006 in the Kuril-Okhotsk region in the Middle Kuril Islands which is a transition zone between the Eurasian continent and the Pacific Ocean. It was followed by numerous strong earthquakes. It is established that the catastrophic earthquake was prepared on a site characterized by increased relative effective pressures which is located at the border of the low-pressure area (Figure 1).Based on data from GlobalCMT (Harvard), earthquake focal mechanisms were reconstructed, and tectonic stresses, the seismotectonic setting and the earthquakes distribution pattern were studied for analysis of the field of stresses in the region before to the Simushir earthquake (Figures 2 and 3; Table ...