Add to ORKGtextabstractCystic fibrosis (CF) is an autosomal recessive disease caused by genetic lesions in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This CFTR gene was cloned in 1989,1-3 and located to the long arm of chromosome 7 (7q3L2). lt encodes the CFTR protein that functions as a adenosine 3',5'-cyclic monophosphate (cAMP)-regulated chloride channe1 in the apical rnembrane of exocrine epithelia, 4,5 like the sweat gland, subrnandibular glands, and the pulmonary, gastrointestinal, hepatobiliaty, and urogenital tracts. In individuals with CF the defective chloride transport leads to abnormal ion and water transport,6 whieh causes dehydration of secretions and malfunctioning of the obstructed exocrine glands, whieh typic...
Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects 1 out of every 2500 indi...
Since identification of the gene responsible for cystic fibrosis (CF) in 1989, significant progress ...
Cystic fibrosis (CF) is a common genetic disorder in the Caucasian population. The gene was identifi...
Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cyst...
Cystic fibrosis (CF) is the most common and fatal autosomal recessive genetic disease in euro-descen...
Genetic, environmental, and stochastic factors contribute to phenotype variation of diseases in chil...
Background The cystic fibrosis (CF) basic defect, caused by dysfunction of the apical chloride chann...
Cystic fibrosis (CF) is a multisystemic autosomal recessive disease caused by a defect in the expre...
textabstractCystic fibrosis (CF) is the most common single gene disorder in The Netherlands and occu...
Background: Cystic fibrosis (CF) is autosomal recessive disorder characterized by chronic respirat...
Abstract The search for the basic defect in cystic fibrosis (CF) has reached a decisive stage sin...
Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF t...
The goal of this research was to better understand the genetic disease, cystic fibrosis. Symptoms an...
Cystic fibrosis (CF) is a multisystem disease, affecting many organs including the liver, intestines...
Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by cystic fibrosis transmembr...
Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects 1 out of every 2500 indi...
Since identification of the gene responsible for cystic fibrosis (CF) in 1989, significant progress ...
Cystic fibrosis (CF) is a common genetic disorder in the Caucasian population. The gene was identifi...
Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cyst...
Cystic fibrosis (CF) is the most common and fatal autosomal recessive genetic disease in euro-descen...
Genetic, environmental, and stochastic factors contribute to phenotype variation of diseases in chil...
Background The cystic fibrosis (CF) basic defect, caused by dysfunction of the apical chloride chann...
Cystic fibrosis (CF) is a multisystemic autosomal recessive disease caused by a defect in the expre...
textabstractCystic fibrosis (CF) is the most common single gene disorder in The Netherlands and occu...
Background: Cystic fibrosis (CF) is autosomal recessive disorder characterized by chronic respirat...
Abstract The search for the basic defect in cystic fibrosis (CF) has reached a decisive stage sin...
Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF t...
The goal of this research was to better understand the genetic disease, cystic fibrosis. Symptoms an...
Cystic fibrosis (CF) is a multisystem disease, affecting many organs including the liver, intestines...
Cystic fibrosis (CF) is a monogenic autosomal recessive disease caused by cystic fibrosis transmembr...
Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects 1 out of every 2500 indi...
Since identification of the gene responsible for cystic fibrosis (CF) in 1989, significant progress ...
Cystic fibrosis (CF) is a common genetic disorder in the Caucasian population. The gene was identifi...