Enhancement and abrogation : modifications of host immune status influence IL-2 and LAK cell immunotherapy

textabstractThis thesis will discuss the role immune cells and the host immune system can play in enhancement and abrogation of this novel immunotherapy with interleukin 2 and lymphokine-activated killer cells. Chapter 3 and 4 will discuss the scoring methods in this intraperitoneal cancer and immunotherapeutic model. Chapter 5 will show the effect of immune cells from a mixed lymphocyte culture on LAK cell generation and LAK cell effect. In Chapter 6 the immune cells were generated in vivo and harvested from the spleen. Their role on LAK cell generation and LAK cell effect are discussed. The effect the host immune system has on IL-2 and LAK cell therapy was tested in a loco-regional - i.p.- tumor model (Chapter 7). Finally Chapter 8 shows the effects of recruitment of immune cells to another - intracutaneous - loco-regional tumor mode