Telomere length (TL) has been associated with aging and mortality, but individual differences are also influenced by genetic factors, with previous studies reporting heritability estimates ranging from 34 to 82%. Here we investigate the heritability, mode of inheritance and the influence of parental age at birth on TL in six large, independent cohort studies with a total of 19 713 participants. The meta-analysis estimate of TL heritability was 0.70 (95% CI 0.64-0.76) and is based on a pattern of results that is highly similar for twins and other family members. We observed a stronger mother-offspring (r=0.42; P-value=3.60 × 10 -61) than father-offspring correlation (r=0.33; P-value=7.01 × 10 -5), and a significant positive association with ...
Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated w...
Telomere length (TL) has been associated with a range of aging outcomes as well as mortality. Recent...
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telo...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Although evidence supports the function of telomere length (TL) as a marker for biological aging, no...
Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer developmen...
In a broad range of species-including humans-it has been demonstrated that telomere length declines ...
Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for ...
Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated w...
Telomere length (TL) has been associated with a range of aging outcomes as well as mortality. Recent...
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telo...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Telomere length (TL) has been associated with aging and mortality, but individual differences are al...
Although evidence supports the function of telomere length (TL) as a marker for biological aging, no...
Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer developmen...
In a broad range of species-including humans-it has been demonstrated that telomere length declines ...
Inherited genetic variation influencing leukocyte telomere length provides a natural experiment for ...
Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated w...
Telomere length (TL) has been associated with a range of aging outcomes as well as mortality. Recent...
Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telo...