Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- Nalls, Michael
- Pankratz, Shane
- Lill, Christina
- Do, Chuong
- Hernandez, Dena
- Saad, Mohamad
- DeStefano, Anita
- Kara, Eleanna
- Bras, Jose
- Sharma, M.
- Schulte, Claudia
- Keller, Margaux
- Arepalli, Sampath
- Letson, Christopher
- Edsall, Connor
- Kallela, Mikko
- Liu, Xinmin
- Pliner, Hannah
- Lee, Joseph H.
- Cheng, Rong
- Ikram, Arfan
- Ioannidis, John
- Hadjigeorgiou, Georgios M.
- Bis, Joshua
- Martinez, Maria
- Perlmutter, Joel
- Goate, Alison M.
- Marder, Karen S.
- Fiske, Brian
- Sutherland, Margaret
- Xiromerisiou, Georgia
- Myers, Richard
- Clark, Lorraine N.
- Zwart, John-Anker
- Hardy, John
- Heutink, Peter
- Chen, Honglei
- Wood, Nicholas
- Houlden, Henry
- Payami, Haydeh
- Brice, A.
- Scott, William
- Gasser, Thomas
- Bertram, Lars
- Eriksson, Nicholas
- Foroud, Tatiana
- Singleton, Andrew
DOIAbstract
We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In to
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