Tumors of the eye and ocular adnexa at the Philippine Eye Research Institute: a 10-year review

Rolando Enrique D Domingo,1,2 Lilibeth E Manganip,1 Rolando M Castro1 1Philippine Eye Research Institute, National Institutes of Health, University of the Philippines, Manila, Philippines; 2Department of Ophthalmology and Visual Sciences, University of the Philippines College of Medicine – Philippine General Hospital, Manila, Philippines Objective: We aimed to identify and describe the clinicopathologic characteristics of tumors of the eye and ocular adnexa at the Philippine Eye Research Institute. Methods: The pathology reports of specimens submitted to the Ocular Pathology Section of the Philippine Eye Research Institute over a 10-year period (2003–2012) were reviewed, and collected data was subjected to descriptive statistical tabulation and analysis. Results: A total of 1,551 histologically confirmed tumors were included. Of these, 254 were from the conjunctiva (155 benign, 99 malignant), 530 from the eyelids (360 benign, 170 malignant), 394 were intraocular tumors (21 benign, 373 malignant), and 373 were from the orbit (231 benign, 142 malignant). Retinoblastoma was the most common tumor of the eye and ocular adnexa in the series, accounting for 43.2% of all malignancies. Squamous cell carcinoma was the most frequent cancer of the conjunctiva, while basal cell carcinoma and sebaceous gland carcinoma were the most common eyelid malignancies. Orbital malignancies had a bimodal age distribution, with rhabdomyosarcoma being most frequent in children, while in adults, lymphoma was most common, followed by lacrimal gland carcinomas. Conclusion: The majority of tumors of the conjunctiva, eyelids, and orbit were benign, while most intraocular tumors were malignant, with retinoblastoma being the most common. Keywords: cancer, ophthalmic, retinoblastoma, clinical characteristic