THE CLINICAL MANIFESTATIONS AND COURSE OF DUODENAL ULCER DISEASE AFTER PERFORATED ULCER

<p><strong>Objective:</strong> to compare clinical manifestations, course, mental status in duodenal ulcer (DU) patients with a history of perforated ulcer and its uncomplicated course.</p><p><strong>Subjects and methods.</strong> One hundred and thirteen patents with DU were examined. Group 1 included 61 patients with uncomplicated DU<br />and Group 2 comprised 52 patients with a history of perforated ulcer. A comparison group consisted of 20 patients who had undergone laparotomy. Physical and mental status examinations, esophagogastroduodenoscopy (EGDS), and 24-hour pH-metry were performed.</p><p><strong>Results.</strong> Classical pain syndrome was observed in 75 % of the patients with uncomplicated DU. Prior to perforation, the pain and dyspeptic syndromes were distinguished only by a significantly lower degree in Group 2; following perforation, the pain syndrome was recorded more frequently, it was more extensive, meal-unrelated, and similar to that in the patients who had undergone laparotomy and had diminished appetite (36.5 %). EGDS showed that the complicated course was accompanied by the significantly higher incidence of erosive esophagitis (21.2 %), gastritis (51.9 %), duodenitis (25.0 %), multiple ulcers (28.8 %), and larger ulcers. 24-hour pH-metry indicated that the level of hyperacidity in Group 2 was higher and the circadian intragastric pH variations were less marked than those in uncomplicated DU. The patients with a history of perforated ulcer showed a high rate of anxiety and depressive changes. </p><p><strong>Conclusion</strong>. In complicated DU, marked monotonic hyperacidity causes common erosive-ulcerative lesions in the gastroduodenal area in relatively mild pain syndrome, late referrals, and long-term ulcer healing. After perforation followed by wound closure, the pain and dyspeptic syndromes become more pronounced, which is associated with anxiety and depressive changes in the mental status, as well as with early referrals and less healing time.