B-Raf and C-Raf kinases have emerged as critical players in melanoma. However, little is known about their role during development and homeostasis of the melanocyte lineage. Here, we report that knockout of B-raf and C-raf genes in this lineage results in normal pigmentation at birth with no defect in migration, proliferation, or differentiation of melanoblasts in mouse hair follicles. In contrast, the double raf knockout mice displayed hair graying resulting from a defect in cell-cycle entry of melanocyte stem cells (MSCs) and their subsequent depletion in the hair follicle bulge. Therefore, Raf signaling is dispensable for early melanocyte lineage development, but necessary for MSC maintenance
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcr...
SummarySomatic stem cell depletion due to the accumulation of DNA damage has been implicated in the ...
Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may b...
SummaryB-Raf and C-Raf kinases have emerged as critical players in melanoma. However, little is know...
L'activation constitutive de la voie RAS/RAF/MEK/ERK est observée dans environ 65% des mélanomes cut...
AbstractBcl2 null mice display a characteristic loss of pigmentation demonstrating the importance of...
c-Myc is involved in the control of diverse cellular processes and implicated in the maintenance of ...
NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was ...
Mice homozygous for the patchwork (pwk) recessive mutation are salt and pepper: their coat contains ...
Melanoma is a form of skin cancer that arises from the neoplastic transformation of melanocytes. Con...
International audienceMIcrophthalmia-associated Transcription Factor (MITF) regulates melanocyte and...
Mutations in the extracellular signal-regulated kinase (ERK) pathway, particularly in the mitogen-ac...
During embryogenesis, the transcription factor, Sox10, drives the survival and differentiation of th...
Identification of the cancer cell of origin is a critical step towards earlier detection of malignan...
The role of B-Raf in cell growth and survival was investigated using primary MEFs lacking B-Raf. Cel...
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcr...
SummarySomatic stem cell depletion due to the accumulation of DNA damage has been implicated in the ...
Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may b...
SummaryB-Raf and C-Raf kinases have emerged as critical players in melanoma. However, little is know...
L'activation constitutive de la voie RAS/RAF/MEK/ERK est observée dans environ 65% des mélanomes cut...
AbstractBcl2 null mice display a characteristic loss of pigmentation demonstrating the importance of...
c-Myc is involved in the control of diverse cellular processes and implicated in the maintenance of ...
NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was ...
Mice homozygous for the patchwork (pwk) recessive mutation are salt and pepper: their coat contains ...
Melanoma is a form of skin cancer that arises from the neoplastic transformation of melanocytes. Con...
International audienceMIcrophthalmia-associated Transcription Factor (MITF) regulates melanocyte and...
Mutations in the extracellular signal-regulated kinase (ERK) pathway, particularly in the mitogen-ac...
During embryogenesis, the transcription factor, Sox10, drives the survival and differentiation of th...
Identification of the cancer cell of origin is a critical step towards earlier detection of malignan...
The role of B-Raf in cell growth and survival was investigated using primary MEFs lacking B-Raf. Cel...
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcr...
SummarySomatic stem cell depletion due to the accumulation of DNA damage has been implicated in the ...
Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may b...