Investigation of the Pupil Diameter Differences in Anisometropic Amblyopia

Pur po se: To study pupil diameter differences between amblyopic and fellow eyes in anisometropic amblyopia. Ma te ri al and Met hod: This study was carried out from medical records of 412 candidates for refractive surgery with excimer laser. 69 patients (21 males and 48 females) with anisometropic amblyopia were enrolled in this study. Mean age of subjects was 33.07±9.07 years. Pupil size measurements were performed with an ocular wavefront analyzer. Amblyopic eyes and fellow eyes were compared with regard to pupil diameter, spherical refractive error, magnitude of astigmatism, spherical equivalent, and best-corrected visual acuity on Snellen chart. Also, correlation analyses were performed to determine correlation coefficients and their significance between selected variables. Re sults: Mean pupil diameter was 5.95±0.90 mm in amblyopic eyes and 6.15±0.90 mm in fellow eyes. Difference in mean pupil diameter between amblyopic and fellow eyes was statistically significant (p=0.01). Mean spherical refractive error (-2.96±6.21 D), mean astigmatic refractive error (-2.87±1.80 D), mean BCVA (0.44±0.19), and mean spherical equivalent (-4.40 ±2.92 D) in amblyopic eyes were statistically different from the values in fellow eyes (p=0.01). In addition, the analyses showed that the correlations between the magnitude of anisocoria and anisometropia, and between the magnitude of anisocoria and the depth of amblyopia were statistically insignificant. Dis cus si on: This study shows a relationship between anisocoria and amblyopia. The existence of such relationship helps both to diagnose amblyopia earlier and to unveil some hidden process in the pathophysiology of amblyopia. (Turk J Ophthalmol 2013; 43: 45-50