Degradation study of different brands of paracetamol by UV spectroscopy

Objective: To investgate the forced degradation study for the determination of degradation of the drug substance. Methods: Paracetamol was exposed to different conditions according to International Conference on Harmonization guideline. The amount of degradation product can be calculated with the help of UV spectrophotometer. The official test limits according to British Pharmacopoeia/United States Pharmacopoeia should not less than and should not more than lapelled amount. Forced degradation of drug substance was exposed to acidic and basic medium of panadol. Forced degradation of drug substance of panadol, disprol and calpol were also observed negligible difference in availability on exposure to UV and heat. This method can be used successfully for studying the stress degradation factors. Because this method is less time consuming and simple and cost effective also. Results: The brands i.e. calpol, panadol and disprol, when they come in contact with different degradation parameters (before, acid, base, heat and UV treatments) according to statistical analysis, the result showed significant values (P < 0.05) which indicated that there was no degradation in any of the brand. Conclusions: The result indicated there is no degradation found in these brands