Add to ORKGA B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat
Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeuti...
Background: Anti-apoptotic mechanism for cell protection on reperfusion may provide a new method to ...
A mild ischemic load applied after a lethal ischemic insult reduces the subsequent ischemia–reperfus...
Background and Objective: Until now there is no drug formulated to prevent Neuronal Loss following B...
Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke...
Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicat...
Objective. We investigated whether and how diazoxide can attenuate brain injury after cardiopulmonar...
Diazoxide has been identified as a mitochondrial, ATP-dependent K+ channel opener, and a potentially...
Diazoxide (DIAZ), an opener of mitochondrial ATP-sensitive K+ channels (mK(ATP)), protects neurons a...
Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke...
Chronic cerebral hypoperfusion, a mild ischemic condition is associated with advancing age and sever...
Aging and dementia are accompanied by cerebral white matter (WM) injury. which is considered to be o...
© 2017 Deryagin, Gavrilova, Gainutdinov, Golubeva, Andrianov, Yafarova, Buravkov and Koshelev. Preco...
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar v...
Diabetes leads to exacerbating brain injury after ischemic stroke, but the underlying mechanisms and...
Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeuti...
Background: Anti-apoptotic mechanism for cell protection on reperfusion may provide a new method to ...
A mild ischemic load applied after a lethal ischemic insult reduces the subsequent ischemia–reperfus...
Background and Objective: Until now there is no drug formulated to prevent Neuronal Loss following B...
Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke...
Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicat...
Objective. We investigated whether and how diazoxide can attenuate brain injury after cardiopulmonar...
Diazoxide has been identified as a mitochondrial, ATP-dependent K+ channel opener, and a potentially...
Diazoxide (DIAZ), an opener of mitochondrial ATP-sensitive K+ channels (mK(ATP)), protects neurons a...
Objective: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke...
Chronic cerebral hypoperfusion, a mild ischemic condition is associated with advancing age and sever...
Aging and dementia are accompanied by cerebral white matter (WM) injury. which is considered to be o...
© 2017 Deryagin, Gavrilova, Gainutdinov, Golubeva, Andrianov, Yafarova, Buravkov and Koshelev. Preco...
Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar v...
Diabetes leads to exacerbating brain injury after ischemic stroke, but the underlying mechanisms and...
Pharmacological modulation of ATP-sensitive potassium channels has become a promising new therapeuti...
Background: Anti-apoptotic mechanism for cell protection on reperfusion may provide a new method to ...
A mild ischemic load applied after a lethal ischemic insult reduces the subsequent ischemia–reperfus...