Antimicrobial properties of nudibranchs tissues extracts from South Andaman, India

Objective: To evaluate the antimicrobial properties of tissues extracts of different nudibranchs such as Phyllidia varicosa, Plakobranchus ocellatus, Phyllidiella rosans and Halgerda stricklandi against bacterial and fungal pathogens. Methods: Nudibranchs tissue samples were subjected to organic solvent extraction for antimicrobial activity by well diffusion method. Results: The crude extract 50 μL (0.2 mg) of Phyllidia varicosa showed the maximum inhibitory zone (22 mm) against Shigella flexneri. Plakobranchus ocellatus extract of 50 μL (0.2 mg) showed the maximum inhibitory zone against Shigella flexneri (22 mm) and Staphylococcus aureus (19 mm) and no significant activity was found against the fungal pathogens. Conclusions: This work reveals that nudibranch tissues contain the antimicrobial secondary metabolites, which leads the significant activity against bacterial pathogens and further emphasizes detailed study on novel drug discovery from nudibranch tissues against certain human bacterial infections