The paper focuses on the explanatory power and limitations of the concept of alienation in educational research. Psychological studies of the phenomena associated with alienation (burnout, extrinsic motivation, cynicism, etc.) are limited by the context of individual mind, whereas the concept of alienation refers to a set of processes unfolding at both individual and sociocultural levels. The paper demonstrates the heuristic possibilities offered by the cultural-historical activity approach to meaning and meaning regulation in the analysis of alien-ation phenomena. The author reviews the findings of empirical studies of alienation in education, as well as existing theoretical works discussing the genesis of alienation and ways to overcome i...