The effect of Teucrium Orientale on Oxidative Stress marker and Liver Function Enzymes in Streptozotocin-Induced Diabetic Rats

Abstract Background & aim: Diabetes is a metabolic disorder characterized by hyperglycemia resulting from perturbation in insulin secretion, action or both. The aim of this study was to investigate the effects of methanol extract of Teucrium orientale on blood glucose and liver damage markers in streptozotocin diabetic rats. Methods: In this experimental research 32 male albino Wistar rats, with body weights of 200 – 240 g were randomly allocated into four groups with 8 rats per each. Control group (normal rats), diabetic rats (received STZ in single dose 60 mg/kg bw, intraperitoneal way and without receive extract), treated normal rats (received T. orientale 200 mg/kg bw, oral gavage) diabetic treated rats (received STZ in single dose 60 mg/kg bw, intraperitoneal way and received T. orientale 200 mg/kg bw, oral gavage). Afterwards 21 days, blood glucose, malondialdehyde (MDA) in liver and the activity of the liver enzymes (ALT ،AST،ALP( were evaluated. The collected data were analyzed using SPSS software via the one-way ANOVA. Resulths: This study demonstrated that sSerum levels of glucose in T. orientale treated diabetic group (222 ± 9.8) were significantly lowerdecreased than in comparison with diabetic ratsgroup (572 ± 8) (P < 0.01).The MDA level in T. orientale treated diabetic group (1.01 ± 0.04) were significantly decreased in comparison with diabetic rats (1.25± 0.54) (P < 0.05). The ALT, AST and ALP levels in T. orientale treated diabetic group were also significantly decreased compared with diabetic rats (P < 0.01). Conclusion: Methanol extract of T. orientale had antidiabetic effects and consequently might alleviate the liver damage caused by streptozotocin-induced diabetes mellitus. Keywords: Diabetes, Teucrium orientale, ALT, AST, ALPLiver enzymes, streptozotoci