Relationship between Polymorphism of Nicotinic Acetylcholine Receptor Gene CHRNA3 and Susceptibility of Lung Cancer

Objective: To investigate the relationship between polymorphism of nicotinic acetylcholine receptor gene CHRNA3 and susceptibility of lung cancer. Methods: Sixty hundred patients with lung cancer and 600 healthy people were respectively selected. TaqMan-MGB probe technique was applied to detect rs3743073 (T > G) genotypes at SNPs site on CHRNA3. The difference of genotype distribution among groups was compared, and its relationship with lung cancer was also investigated. Results: There was statistical significance regarding the distributions of CHRNA3 rs3743073 (T> G) genotype and allele frequencies in patients with lung cancer and healthy people (P < 0.05). By comparison to the patients with TT genotype, the risk of developing lung cancer in patients with TG and GG genotypes was increased 1.68 times (95%CI ＝ 1.30 － 2.19, P < 0.05) and 1.30 times (95%CI ＝ 1.05 － 1.61, P < 0.05), respectively, while the risk of developing lung cancer in patients with rs3743073G (TG and GG) was increased 0.65 times (95%CI ＝ 0.50 － 0.84, P < 0.05) . Further analysis demonstrated that of the patients more than 60 years old, male and smoking, the risk of developing lung cancer in those with rs3743073G mutant genotypes was elevated significantly (P < 0.05). Conclusion: The risk of developing lung cancer in patients with rs3743073G mutant genotypes of CHRNA3 gene is increased markedly, especially in those more than 60 years old, males and smoking ones