RELATIONSHIP BETWEEN PSYCHOEMOTIONAL DISORDERS WITH INCREASING THICKNESS OF INTIMA-MEDIA COMPLEX AND VASCULAR MICRO INFLAMMATION DEVELOPMENT

<p><strong>Objective</strong> — to study relationship of psycho-emotional factors and indicators of intravascular microinflammation and vascular changes in healthy patients.</p><p><br /><strong>Materials and methods.</strong> To study psycho-emotional status in 239 healthy patients aged 30 to 60 years, markers of inflammation (C-reactive<br />protein — CRP and cytokines — tumor necrosis factor-α — TNF-α, interleukins — IL-1, -4, - 8) and ultrasonography of the vascular wall of the common carotid artery with the definition of the thickness of intimamedia.</p><p><br /><strong>Results.</strong> In group with high levels of emotional stress significant increase in the thickness of intima media and increase in plasma concentrations<br />of markers of vascular mikrovospaleniya — CRP, IL-1, IL-8, TNF-α were showed. These correlation analysis indicated relationship between thickness of intima-media, psychoemotional factors and markers of vascular microinflamation. Calculating odds ratios revealed that thickening of the intima-media process such psycho-emotional disorders like anxiety, depression and fatigue are of great importance.</p><p><br /><strong>Conclusion.</strong> Otherwise development of latent intravascular inflammation and thickening intima-media complex of common carotid artery is registered inhealthy patients with presence of psycho-emotional disorders (depression, anxiety, fatigue).