Cytochrome P450 gene expression is altered by various chemical compounds. In this study, we used nuclear factor erythroid 2-related factor 2 (Nrf2)–deficient (Nrf2−⧸−) mice to investigate the involvement of Nrf2 in Cyp2b10 and Cyp2a5 gene expression. Phorone, an Nrf2 activator, strongly increased Cyp2b10 and Cyp2a5 mRNA as well as Nrf2 target genes, including NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1, in wild-type mouse livers 8 h after treatment. The phorone-induced mRNA levels in Nrf2−⧸− mouse livers were lower than that in wild-type mouse livers. Nrf2−⧸− mice showed attenuated Cyp2b10 and Cyp2a5 induction by phenobarbital, a classical Cyp2b inducer. These findings suggest that the Nrf2 pathway is involved in Cyp2b10 and Cyp2a...
Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (AR...
Exposure to toxicants that create oxidative stress, such as isothiocyanates (ITCs) and heavy metals,...
An overview is provided of the cancer chemoprevention actions of phenolic antioxidants and 6-ethoxy-...
AbstractCytochrome P450 gene expression is altered by various chemical compounds. In this study, we ...
a b s t r a c t Cytochrome P450 gene expression is altered by various chemical compounds. In this st...
AbstractMouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative c...
129 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.A new in vivo protocol, mouse...
金沢大学医薬保健研究域薬学系Human CYP2A6 is responsible for the metabolism of nicotine and coumarin as well as the...
<div><p>Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a ...
Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative common fe...
Evidence suggests that the Nrf2 transcription factor participates in the regulation of expression of...
Cytochrome P450 (CYP) plays a central role in the metabolism of endogenous and exogenous compounds. ...
Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (AR...
AbstractThe transcription factor Nrf2 is a master regulator of cellular defence: Nrf2 null mice (Nrf...
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcrip-tion factor critical for protectio...
Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (AR...
Exposure to toxicants that create oxidative stress, such as isothiocyanates (ITCs) and heavy metals,...
An overview is provided of the cancer chemoprevention actions of phenolic antioxidants and 6-ethoxy-...
AbstractCytochrome P450 gene expression is altered by various chemical compounds. In this study, we ...
a b s t r a c t Cytochrome P450 gene expression is altered by various chemical compounds. In this st...
AbstractMouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative c...
129 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001.A new in vivo protocol, mouse...
金沢大学医薬保健研究域薬学系Human CYP2A6 is responsible for the metabolism of nicotine and coumarin as well as the...
<div><p>Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a ...
Mouse cytochrome P450 2A5 (CYP2A5) is upregulated in various liver diseases and a putative common fe...
Evidence suggests that the Nrf2 transcription factor participates in the regulation of expression of...
Cytochrome P450 (CYP) plays a central role in the metabolism of endogenous and exogenous compounds. ...
Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (AR...
AbstractThe transcription factor Nrf2 is a master regulator of cellular defence: Nrf2 null mice (Nrf...
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcrip-tion factor critical for protectio...
Nrf2 controls the basal expression of genes regulated through the antioxidant responsive element (AR...
Exposure to toxicants that create oxidative stress, such as isothiocyanates (ITCs) and heavy metals,...
An overview is provided of the cancer chemoprevention actions of phenolic antioxidants and 6-ethoxy-...