In Drosophila, Notch and EGFR signalling pathways are closely intertwined. Their relationship is mostly antagonistic, and may in part be based on the phosphorylation of the Notch signal transducer Suppressor of Hairless [Su(H)] by MAPK. Su(H) is a transcription factor that together with several cofactors regulates the expression of Notch target genes. Here we address the consequences of a local induction of three Su(H) variants on Notch target gene expression. To this end, wild-type Su(H), a phospho-deficient Su(H)MAPK-ko and a phospho-mimetic Su(H)MAPK-ac isoform were overexpressed in the central domain of the wing anlagen. The expression of the Notch target genes cut, wingless, E(spl)m8-HLH and vestigial, was monitored. For the latter two...
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal ...
AbstractThe transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription fac...
AbstractBackground: Members of the Notch family of receptors mediate a process known as lateral inhi...
AbstractIn Drosophila, Notch and EGFR signalling pathways are closely intertwined. Their relationshi...
AbstractSuppressor of Hairless [Su(H)] is a DNA-binding protein that is the main intracellular trans...
Throughout the animal kingdom, the Notch signalling pathway allows cells to acquire diversified cell...
AbstractThe transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription fac...
<div><p>The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch ...
AbstractBackground: Members of the Notch family of receptors mediate a process known as lateral inhi...
The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway tha...
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal ...
The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor...
Notch signaling is iteratively used throughout development to maintain stem cell potential or in oth...
<div><p>Throughout the animal kingdom, the Notch signalling pathway allows cells to acquire diversif...
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal ...
AbstractThe transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription fac...
AbstractBackground: Members of the Notch family of receptors mediate a process known as lateral inhi...
AbstractIn Drosophila, Notch and EGFR signalling pathways are closely intertwined. Their relationshi...
AbstractSuppressor of Hairless [Su(H)] is a DNA-binding protein that is the main intracellular trans...
Throughout the animal kingdom, the Notch signalling pathway allows cells to acquire diversified cell...
AbstractThe transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription fac...
<div><p>The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch ...
AbstractBackground: Members of the Notch family of receptors mediate a process known as lateral inhi...
The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway tha...
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal ...
The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor...
Notch signaling is iteratively used throughout development to maintain stem cell potential or in oth...
<div><p>Throughout the animal kingdom, the Notch signalling pathway allows cells to acquire diversif...
Notch signaling is conserved in most multicellular organisms and plays critical roles during animal ...
AbstractThe transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription fac...
AbstractBackground: Members of the Notch family of receptors mediate a process known as lateral inhi...