Exposure to repetitive startling stimuli induces habitation, a simple form of learning. Despite its simplicity, the precise cellular mechanisms by which repeated stimulation converts a robust behavioral response to behavioral indifference are unclear. Here, we use head-restrained zebrafish larvae to monitor subcellular Ca2+ dynamics in Mauthner neurons, the startle command neurons, during startle habituation in vivo. Using the Ca2+ reporter GCaMP6s, we find that the amplitude of Ca2+ signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation. Co...
Interindividual variation in behavior and brain activity is universal and provides substrates for na...
Scientists have long been fascinated by how anatomical structures in the brain can generate the dive...
The ability to evade a predator is crucial to the survival of an animal. Throughout the history of e...
SummaryExposure to repetitive startling stimuli induces habitation, a simple form of learning. Despi...
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being ...
The zebrafish larva has been a valuable model system for genetic and molecular studies of developmen...
BackgroundThe ability to filter sensory information into relevant versus irrelevant stimuli is a fun...
The zebrafish larva has been a valuable model system for genetic and molecular studies of developmen...
Summary: Sensory experiences dynamically modify whether animals respond to a given stimulus, but it ...
Inter-individual behavioral variation is thought to increase fitness and aid adaptation to environme...
While the effects of social experience on nervous system function have been extensively investigated...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for ad...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
Interindividual variation in behavior and brain activity is universal and provides substrates for na...
Scientists have long been fascinated by how anatomical structures in the brain can generate the dive...
The ability to evade a predator is crucial to the survival of an animal. Throughout the history of e...
SummaryExposure to repetitive startling stimuli induces habitation, a simple form of learning. Despi...
Habituation allows animals to learn to ignore persistent but inconsequential stimuli. Despite being ...
The zebrafish larva has been a valuable model system for genetic and molecular studies of developmen...
BackgroundThe ability to filter sensory information into relevant versus irrelevant stimuli is a fun...
The zebrafish larva has been a valuable model system for genetic and molecular studies of developmen...
Summary: Sensory experiences dynamically modify whether animals respond to a given stimulus, but it ...
Inter-individual behavioral variation is thought to increase fitness and aid adaptation to environme...
While the effects of social experience on nervous system function have been extensively investigated...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
The Mauthner-cell (M-cell) system of teleost fish has a long history as an experimental model for ad...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
The Mauthner cell (M-cell) is a command-like neuron in teleost fish whose firing in response to aver...
Interindividual variation in behavior and brain activity is universal and provides substrates for na...
Scientists have long been fascinated by how anatomical structures in the brain can generate the dive...
The ability to evade a predator is crucial to the survival of an animal. Throughout the history of e...