PROTHROMBIN FRAGMENT 1.2 (F1.2) IN RELATION WITH PLASMA LEAKAGE DAN THROMBOCYTOPENIA IN DENGUE INFECTION

<p><strong>Abstract</strong></p> <p><strong> </strong></p> <p>Clinical manifestations of Dengue haemorrhagic fever are plasma leakage and thrombocypenia. Both manifestations are thought to be caused by an increased thrombin level due to activation of coagulation. The aim of this study is to look for any association between F1.2 level and plasma leakage and also between F1.2 level and thrombocytopenia in Dengue infected patients. This study used EDTA plasma from patients infected with Dengue virus. The study design was cross sectional. The thrombin level was measured by the prothrombin fragment 1.2 (F1.2) level. In this study, it was found that the F1.2 level in patients with plasma leakage (mean ± 2 SD) 147.4 ± 105.82 pg/mL is significantly higher compared to patients without plasma leakage 51.3 ±39.92 pg/mL, and the F1.2 level in critical phase has a median of 186.3 (108.6-223.2) pg/mL which is significantly higher compared to convalescent phase 46.5(27.4-51.9) pg/mL. Also it was found that a medium negative correlation between F1.2 level and the thrombocyte count existed, r = - 0.609. The results of the study suggest that there was increased coagulation activation at critical phase in patients infected with Dengue virus associated with plasma leakage and thrombocytopenia.</p> <p>Keywords: <em>Dengue </em>infection; plasma leakage; thrombin; prothrombin fragment (F1.2); trombocytopenia